The Best Natural Product for Pain: Serrapeptase

THE SERRAPEPTASE ENZYME

Enzymes, called active proteins, are generators of life in the organism and are essential for its growth and repair. The health of every cell in our body depends, in part, on enzymes. In other words, without enzymes you cannot have health.

Functions of Enzymes

• Absorb food.
• Getting proteins transformed into muscle.
• Clean blood residue.
• Improve the immune system.
• Support the function of vital organs.
• Eliminate Co2 from the lungs.

There are mainly three types of enzymes:

• Digestive: They break down food into micro particles.
• Metabolic: They use these micro particles to maintain the body's functions.
• Purifying: These are the enzymes that are responsible for cleaning undigested substances and unnecessary tissues such as plaques in the arteries or waste in the blood. They act as anti-inflammatory to combat infections and tissue damage.

Of all the purifying enzymes, there is one that has proven to be the most effective and that is serrapeptase . Also called serratiopeptidase, it was isolated from the microorganism Serratia E15. It is the enzyme that the silkworm uses to dissolve its shell and become a butterfly.

Serrapeptase was classified as the “miracle enzyme” by the German researcher Hans Nieper when he verified that this enzyme had the ability to eliminate atheroma plaques without any harm to healthy cells. This enzyme is capable of dissolving non-living tissues such as cysts, blood clots and plaques in the arteries.

The therapeutic use of Serrapeptase is not new since the medical community has been researching and using this enzyme for 30 years. Today it is used throughout Europe and Asia in clinical settings as an effective alternative to ibuprofen and NSAIDs (non-steroidal anti-inflammatory drugs).

Properties of Serrapeptase

Among the many properties of Serrapeptase, the following stand out:

• Reduces or even eliminates inflammation.
• Eliminates protein residues from muscle and joint injuries, which achieves a reduction or remission of pain.
• Prevents and reduces the formation of plaque in the arteries.
• Eliminates non-cancerous cysts.
• Breaks up stored mucus from the airways.

It is because of all these properties that serrapeptase has that it has been used in a wide variety of situations such as:

• Chronic pain
• Arthritis
• Traumatic injuries (such as sprains and torn ligaments), and also inflammation in patients during the postoperative period.
• Dental interventions
• Bronchitis and other respiratory tract disorders.
• Carpal Tunnel Syndrome
• COPD (Chronic Obstructive Pulmonary Disease)
• Migraines and inflammatory headaches
• Cysts
• Sinusitis
• Arteriosclerosis, as in the case of the carotid arteries.
• Inflammatory diseases of the nose, ears and throat.
• Herniated discs

This enzyme has also been used in the treatment of Lyme Disease. The microorganisms that promote this disease are Borrelia, Babesia, Bartonella and Elichia. These pathogens protect themselves from our immune system with a layer of fibrin. That way they go unnoticed. Serrapeptase dissolves this layer of fibrin, revealing the bacteria so that our body can identify and eliminate them.

The possible benefits of Serrapeptase are also being studied in the following conditions:

• Back and neck pain
• Regeneration of damaged nervous tissue
• Multiple sclerosis
• Chronic ear infections
• Allergies
• Ulcers
• Osteoporosis
• prostate problems
• Rheumatoid arthritis
• Sports injuries (both prevention and recovery)
• Postoperative scars and injuries
• varicose veins
• Cancer
• Decrease in C-reactive protein.

How Serrapeptase is Used:

1. Take it on an empty stomach.
2. The ideal time is when you get up or go to bed.
3. The ideal minimum dose is 250,000 IU/day. Many companies offer doses much lower than this but effectiveness is not achieved, which discredits the properties of the enzyme. The dose is one of the keys .
4. It is recommended for a period of 8 months to clean tissues from lesions, cysts, mucus...etc.
5. Serrapeptase is affected by gastric juices, so it is necessary to take it in an enteric capsule. This enteric capsule facilitates intestinal absorption and improves its effectiveness. The problem is that most enteric capsules use pphalates, but these are harmful to our health . Nutilab Serrapeptase is the only serrapeptase on the market that does NOT use pphalates in its enteric capsule .
6. The use of serrapeptase does not have any side effects.

References and Bibliography

Scientific References of Serrapeptase
Inflammation

Clinical uses of the anti-inflammatory enzyme Serrapeptase.
Effect of some clinically used proteolytic enzymes on inflammation in rats. Indian J Pharm Sci. 2008 Jan;70(1):114-7. doi: 10.4103/0250-474X.40347. Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T, Murakami K, Komatsu H, Hirata M, Arai T, et al.
Augmentation by Serrapeptase of tissue permeation by cefotiam (Japanese). JpnJAntibiot. 1986; 39(3): 761-71. Marly, M. Enzymotherapie anti-inflammatoire a l'aide de la Serrapeptase: clinical results in traumatology in
ENT. C RTherapeut. 3:9-19,1985.
 
Yamazaki, J. et al. Anti-inflammatory activity of Serrapeptase, a protease produced by a strain of Serratia. Folia Pharmacol.Japan. 6^302-314,1967.

Prospective Inflammation and Pain
A decrease in prospective inflammation and pain after third molar surgery is confirmed in a control group using serrapeptase; Other anti-inflammatory benefits of this enzyme were also observed in the postoperative period.

Effect of the proteolytic enzyme Serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. Int J Oral Maxillofac Surg. 2008
Mar;37(3):264-8. doi: 10.1016/j.ijom.2007.11.011. Epub 2008 Feb 12.
Esch PM, Gemgross H. Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joints in treatment with Serrapeptase
a prospective study (German).FortschrMed. 1989; 107(4):67-8, 71-2.
Matsudo, A. et at. Effect of Serrapeptase on inflammatory oedema following operation for thyroid disease. Med.Consult. New Remedy 18:171-175, 1981.
 
Asthma
Serrapeptase improves the dissolution of sputum in asthmatic patients.

Tago.T. and Mitsui, S. Effects of Serrapeptase in dissolution of sputum, especially in patients with bronchial asthma. Jap.Clin. Exp. Med. 49:222-228, 1972.
 
Breast Engorgement
An anti-inflammatory drug, whose content includes the enzyme serrapeptase, proves to be “an effective way to treat breast engorgement.”
 
Kee WH. Tan SL, Lee V. Salmon YM. The treatment of breast engorgement with Serrapeptase: a randomized double blind controlled trial. Singapore MedJ. 1989:30(1): 48-54.
Aso T. et al. Breast engorgement and its treatment: Clinical effects of (Serrapeptase) an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynecology (Japanese). 1981:33:371-9.
 
Burns
Serrapeptase, when applied as an oral anti-inflammatory to rats with burns, has been shown to be effective in suppressing the activation of fibrinolysis.
 
Kakinumu, A. et al. Regression of fibrinolysis in scalded rats by administration of Serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982.
 
Carpal tunnel syndrome
Research suggests that Serrapeptase therapy may be a useful alternative in the treatment of Carpal Tunnel Syndrome.

A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 1999 Dec;47(12):1170-2.
 
Lung diseases
The proteolytic enzyme Serrapeptase has wide clinical use in Japan and may offer benefits in mucus clearance and sputum viscoelasticity in patients with chronic airway diseases.

Effect of the proteolytic enzyme Serrapeptase in patients with chronic airway disease. Respirology. 2003 Sep;8(3):316-20.
 
Chronic Bronchitis
Patients treated with serrapeptase have shown excellent results in reducing the frequency of cough and expectoration, as well as the amount of sputum, compared with a group treated with placebo.

Kase, Y. et al. A new method for evaluating mucolytic expectorant activity and its application. II. Application to two proteolytic enzymes, Serrapeptase and seaprose.
Arzneimittelforschung 32:374-378,1982.
Braga, PC et al. Effects of Serrapeptase on muco-ciliary clearance in patients with chronic bronchitis. Curr.Ther. Res. 29(5): 738-744,1981.
 
Chronic Obstructive Pulmonary Disease (COPD)
Serrapeptase is being used in chronic obstructive bronchopneumopathy.

Carratu, L. et al. Physio-chemical and rheological research
on mucolytic activity of Serrapeptase in chronic bronchopneumopathies.
Curr.Ther. Res 28(6):937-951. 1980.
Majima. Y. et al. Effects of orally administered drugs on dynamic viscoelasticity of human nasal mucus. Am. Rev. Respit. Dis. 141:79-83.1990. Majima Y, Inagaki M, Hirata K. Takeuchi K, Morishita A, Sakakura Y.
The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988; 244(6):355-9.
Marriott, C. Modification of the rheoloaical properties of mucus by drugs. Adv. Exp. Med. Biol. 144^75-84, 1982.
 
Ear, Nose and Throat Disorders
Serrapeptase offers fibrinolytic, antiedemic and anti-inflammatory activity in patients with chronic ear, nose or throat pathologies.

Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicenter, double-blind, randomized trial versus placebo. Giving the answer to Pain, Chronic Inflammation, and Clogged Arteries
© 2001-2018 Naturally Healthy Publications. All rights reserved. 355 I
J Int Med Res. 1990 Sep-Oct;18(5):379-88.
 
Infections
Proteolytic enzymes are considered a new strategy in the treatment of prostate infections.

Selan L, Berlutti F, Passariello C. Comodi-Ballanti MR, Thaller MC. Proteolytic enzymes: a new treatment strategy for prosthetic infections? Antimicrob Agents Cheroother. 1993; 37(12): 2618-21.
 
Sinusitis
Patients suffering from laryngitis, rhinopharyngitis and sinusitis noticed rapid improvement after using Serrapeptase.

A technique for quantitative cytology of nasal secretions. Eur Arch Otorhinolaryngol. 1991;248(7):406-8. Harad, Y.
Clinical efficacy of Serrapeptase on buccal swelling after radical operation for chronic sinusitis. IgakuAyumi 123:768-778.1982. Mizukoshi, D. et al.
A double blind clinical study of Serrapeptase in the treatment of chronic sinusitis.
IgakuAyrni 109:50-62.1979. Odagiri, J. et al. Clinical applications of Serrapeptase in sinusitis. Consult Med. New Remedy 6:201-209, 1979. Fujitani, T. et al.
Effect of anti-inflammatory agent on transfer of antibiotics to the maxillary sinus mucosa in chronic sinusitis. Otorhinolaryngol. Clin. North Am. 66:557-

565. 1976.

 
Healing of wounds.
Research supports that wounds can heal faster with Serrapeptase and Metronidazole therapy
Development of serratiopeptidase and metronidazole based alginate microspheres for wound healing. Artif Cells Blood SubstitImmobilBiotechnol. 2011 Feb;39(1):44-50. doi:10.3109/10731199.2010.494580. Epub 2010 Jun 17.
Research and References
Intestinal Absorption
Intestinal absorption of Serrapeptase is transformed into a more enzymatically active form in the circulatory system in tests with rats.

Miyata, K. Intestinal absorption of Serrapeptase. J Appl Biochem. 1980:2:111-16.

Alzheimer's
The proteolytic enzymes Serrapeptase and/or Nattokinase can effectively modulate certain factors that characterize Alzheimer's disease.

Serrapeptase and Nattokinase™ intervention for relieving Alzheimer's disease pathophysiology in rat model. Hum ExpToxicol. 2013 Jul;32(7):721-35. doi:
10.1177/0960327112467040.
 
Antibiotic Resistance.
Serrapeptase could be used to reduce resistance to antibiotics.

A new anti-infective strategy to reduce the spread of antibiotic resistance by the action on adhesion-mediated virulence factors in Staphylococcus aureus. MicrobPathog. 2013 Oct;63:44-53. doi: 10.1016/j.micpath.2013.05.003. Epub
2013 Jun 26.

Juan Torrontegui
Naturopath and Higher Technician in Dietetics